Ireland head coach Andy Farrell has made four changes to the team. With Jonathan Sexton out due to injury, Ryan will become the 107th player to captain Ireland and the fourth-youngest Ireland captain of the professional era, following on from Peter O’Mahony, Brian O’Driscoll (both 23) and Paul O’Connell (24).
Quinn Roux strong performance against Wales earns him a second successive start at lock, with an unchanged tight five completed by Cian Healy, Ronan Kelleher and Andrew Porter.
CJ Stander returns to the blindside berth, which he last filled against Scotland in February. Peter O’Mahony shifts to openside and Caelan Doris continues at number 8.
Jamison Gibson-Park retains the number 9 jersey. It is an all-Leinster half-back pairing as Ross Byrne, whose only previous start was against England last year, replaces the injured Sexton.
The final two changes see Bundee Aki and Keith Earls come back into the starting XV. Aki, a try scorer against England in August 2019, replaces the injured Robbie Henshaw in midfield where he partners Chris Farrell.
Having recovered from a back injury, Earls will win his 86th cap on the right-wing. It is a second successive start at full-back for Hugo Keenan, while James Lowe continues on the left following his try-scoring debut.
Ireland squad: 15. Hugo Keenan (UCD/Leinster) 3 14. Keith Earls (Young Munster/Munster) 85 13. Chris Farrell (Young Munster/Munster) 11 12. Bundee Aki (Galwegians/Connacht) 28 11. James Lowe (Leinster) 1 10. Ross Byrne (UCD/Leinster) 8 9. Jamison Gibson-Park (Leinster) 3 1. Cian Healy (Clontarf/Leinster) 101 2. Ronan Kelleher (Lansdowne/Leinster) 4 3. Andrew Porter (UCD/Leinster) 29 4. Quinn Roux (Galwegians/Connacht) 13 5. James Ryan (UCD/Leinster) (capt) 29 6. CJ Stander (Shannon/Munster) 43 7. Peter O’Mahony (Cork Constitution/Munster) 70 8. Caelan Doris (St. Mary’s College/Leinster) 5
Replacements: 16. Rob Herring (Ballynahinch/Ulster) 13 17. Ed Byrne (UCD/Leinster) 3 18. Finlay Bealham (Buccaneers/Connacht) 12 19. Iain Henderson (Academy/Ulster) 55 20. Will Connors (UCD/Leinster) 3 21. Conor Murray (Garryowen/Munster) 84 22. Billy Burns (UIster) 1 23. Jacob Stockdale (Lurgan/Ulster) 30