Owen Farrell will captain the side at fly-half while Ben Youngs will play at scrum-half having hit 100 caps against Italy. Henry Slade starts at the inside centre with Ollie Lawrence, who made his England debut in Rome, starts at outside centre.
Jonathan Joseph moves to the wing, along with Jonny May. Elliot Daly is back from injury and he will line up at full-back.
Ellis Genge starts at loosehead as Will Stuart makes his first start for England at tighthead. Jamie George keeps his place at hooker.
Charlie Ewels and Joe Launchbury complete the tight five. Billy Vunipola will continue at No. 8, while Maro Itoje will play at blindside flanker. Jack Willis will make his England debut at open-side flanker.
England will be hoping to shine in the Autumn Nations having recently won the Six Nations
England: 15. Elliot Daly (Saracens, 43 caps) 14. Jonathan Joseph (Bath Rugby, 51 caps) 13. Ollie Lawrence (Worcester Warriors, 1 cap) 12. Henry Slade (Exeter Chiefs, 30 caps) 11. Jonny May (Gloucester Rugby, 57 caps) 10. Owen Farrell (c) (Saracens, 83 caps) 9. Ben Youngs (Leicester Tigers, 100 caps) 1. Ellis Genge (Leicester Tigers, 19 caps) 2. Jamie George (Saracens, 50 caps) 3. Will Stuart (Bath Rugby, 4 caps) 4. Charlie Ewels (Bath Rugby, 16 caps) 5. Joe Launchbury (Wasps, 65 caps) 6. Maro Itoje (Saracens, 39 caps) 7. Jack Willis (Wasps, uncapped) 8. Billy Vunipola (Saracens, 52 caps)
Replacements: 16. Tom Dunn, (Bath Rugby, 1 cap) 17. Mako Vunipola (Saracens, 60 caps) 18. Kyle Sinckler (Bristol Bears, 36 caps) 19. Ben Earl (Bristol Bears, 4 caps) 20. Tom Curry (Sale Sharks, 24 caps) 21. Dan Robson (Wasps, 3 caps) 22. Max Malins (Bristol Bears, uncapped) 23. Joe Marchant (Harlequins, 3 caps)