Head Coach Joe Schmidt has included two uncapped players in his match day 23 to face Italy in Soldier Field,Chicago.
Rhys Ruddock will wear the armband in Chicago and he is joined in the backrow by Josh van der Flier and Jack Conan.
Bundee Aki will continue to provide his services at inside center and will pair up with Garry Ringrose at outside center to form a strong combination in the midfield.Jordan Larmour is named at fullback as Andrew Conway and Jacob Stockdale tasked at manning the wings.Joey Carbery will control the proceedings at fly half.
The substitutes include the two uncapped players Ross Byrne and Will Addison who will be hoping to make their debut in the green and white colours.Others named in the reserves include Sean Cronin,Dave Kilcoyne,Findlay Bealham,Devin Toner,Jordi Murphy and John Cooney.
Ireland: 15 Jordan Larmour, 14 Andrew Conway, 13 Garry Ringrose, 12 Bundee Aki, 11 Jacob Stockdale, 10 Joey Carbery, 9 Luke McGrath, 8 Jack Conan, 7 Josh van der Flier, 6 Rhys Ruddock (c), 5 Quinn Roux, 4 Tadhg Beirne, 3 Andrew Porter, 2 Niall Scannell, 1 Jack McGrath
Replacements: 16 Sean Cronin, 17 Dave Kilcoyne, 18 Finlay Bealham, 19 Devin Toner, 20 Jordi Murphy, 21 John Cooney, 22 Ross Byrne, 23 Will Addison
Date: Saturday, November 3
Venue: Soldier Field, Chicago
Referee: Nigel Owens (Wales)
Assistant referees: Romain Poite (France), Alexandre Ruiz (France)
TMO: David Ardrey (USA)